Simulate the synthesis of aspirin (acetylsalicylic acid) from salicylic acid and acetic anhydride.
Observe the esterification reaction and crystallization of aspirin.
Aspirin Synthesis Setup
Salicylic Acid
Acetic Anhydride
Mix Reactants
Heat Mixture
Crystallize
Reset Experiment
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Observation:
Click "Mix Reactants" to begin the aspirin synthesis process.
The Science Behind Aspirin Synthesis
Chemical Reaction:
C7 H6 O3 + (CH3 CO)2 O → C9 H8 O4 + CH3 COOH
Reaction Mechanism:
Step 1: Protonation of acetic anhydride by acid catalyst (Hâ‚‚SOâ‚„)Step 2: Nucleophilic attack by salicylic acid's hydroxyl groupStep 3: Formation of acetylsalicylic acid (aspirin) and acetic acidStep 4: Crystallization of aspirin upon cooling
Key Components:
Component
Role
Properties
Salicylic Acid
Reactant
Phenolic compound with -OH and -COOH groups
Acetic Anhydride
Reactant
Acetylating agent, reacts with -OH group
Sulfuric Acid
Catalyst
Protonates acetic anhydride
Aspirin
Product
White crystalline solid, mp 135°C
Procedure Steps:
Mix salicylic acid with acetic anhydride
Add a few drops of concentrated sulfuric acid
Heat gently for 10-15 minutes
Cool the reaction mixture to crystallize aspirin
Filter and wash the crystals
Applications of Aspirin:
- Pain relief (analgesic)
